All right, here are some details from Mod Mark about the "new/old" Wilderness (click on the image there to see screenshots in full resolution).
Short summary (as far as understand what is going on):
- A lot of relocation is going to take place. Minigames will be moved as well as quests.
- Clues will be updated, but I don't think they will be removed from wilderness completely. Probably, we will just get less trips there.
- Jagex is confident that they'll keep bots and RWT at bay with new technology (or technologies)
- There will be no special PvP worlds anymore
- A lot of stuff still undecided (gravestones, abyss, potions, weapons etc.)